Kang B P, Mehta U, Bansal M P
Department of Biophysics, Panjab University, Chandigarh, India.
Arch Physiol Biochem. 1997 Oct;105(6):603-6. doi: 10.1076/apab.105.6.603.3271.
The aim of the present study was to examine the activity of nitric oxide synthase (NOS, EC 1.14.23) in plasma of high fat diet (HFD, 2% cholesterol and 100 g table butter/kg diet) and HFD + selenium (Se, 1 ppm as sodium selenite) fed rabbits for three months. Significant increase in the serum cholesterol and triglyceride levels in HFD fed group was observed. The activity of NOS also increased very significantly. However in Se supplemented animals, there was a significant reduction in serum cholesterol as well as in plasma NOS activity relative to HFD fed animals. It is concluded that the protective effect of Se on HFD induced NOS activity acts probably through its antioxidant/inhibitory action.
本研究的目的是检测高脂饮食（HFD，2%胆固醇和100克食用黄油/千克饮食）以及高脂饮食+硒（Se，1 ppm亚硒酸钠）喂养三个月的兔子血浆中一氧化氮合酶（NOS，EC 1.14.23）的活性。观察到高脂饮食喂养组的血清胆固醇和甘油三酯水平显著升高。NOS的活性也非常显著地增加。然而，相对于高脂饮食喂养的动物，补充硒的动物血清胆固醇以及血浆NOS活性显著降低。得出的结论是，硒对高脂饮食诱导的NOS活性的保护作用可能是通过其抗氧化/抑制作用实现的。
