Güleç S, Büyükkidan B, Oral N, Ozcan N, Tanriverdi B
Department of Anaesthesiology, Medical School of Osmangazi University, Eskişehir, Turkey.
Eur J Anaesthesiol. 1998 Mar;15(2):161-5.
Sixty children undergoing inguinal or urogenital surgery were allocated randomly to three groups to receive a caudal injection of either 0.125% bupivacaine 0.75 mL kg-1 with 0.5% midazolam 50 micrograms kg-1 (n = 20) or with 1% morphine chlorhydrate 0.05 mg kg-1 (n = 20), or bupivacaine alone (n = 20) after surgery under general anaesthesia. There were no significant changes in heart rate, blood pressure, respiratory rate or oxygen haemoglobin saturation values in all groups, and there were no significant differences in the incidence of vomiting and pruritus between the groups (P > 0.05). Sedation scores were higher in the bupivacaine-midazolam and the bupivacaine-morphine groups than in the bupivacaine group at 8-12 h post-operatively (P < 0.01). The durations of analgesia were 21.15 +/- 1.2 h in the bupivacaine-midazolam group, 14.50 +/- 1.6 h in the bupivacaine-morphine group and 8.15 +/- 1.3 h in the bupivacaine group. Differences between the bupivacaine-midazolam group and the bupivacaine group (P < 0.001), the bupivacaine-midazolam group and the bupivacaine-morphine group (P < 0.01), and the bupivacaine-morphine group and the bupivacaine group (P < 0.01) were significant. It is suggested that caudal administration of a bupivacaine-midazolam mixture produces a longer duration of post-operative analgesia than a bupivacaine-morphine mixture and bupivacaine alone with sedation for 8-12 h post-operatively.
60名接受腹股沟或泌尿生殖系统手术的儿童被随机分为三组，在全身麻醉手术后接受骶管注射，分别为：0.125%布比卡因0.75 mL/kg加0.5%咪达唑仑50微克/kg（n = 20），或加1%水合吗啡0.05 mg/kg（n = 20），或仅注射布比卡因（n = 20）。所有组的心率、血压、呼吸频率或氧合血红蛋白饱和度值均无显著变化，且各组间呕吐和瘙痒的发生率无显著差异（P > 0.05）。术后8 - 12小时，布比卡因 - 咪达唑仑组和布比卡因 - 吗啡组的镇静评分高于布比卡因组（P < 0.01）。布比卡因 - 咪达唑仑组的镇痛持续时间为21.15±1.2小时，布比卡因 - 吗啡组为14.50±1.6小时，布比卡因组为8.15±1.3小时。布比卡因 - 咪达唑仑组与布比卡因组之间（P < 0.001）、布比卡因 - 咪达唑仑组与布比卡因 - 吗啡组之间（P < 0.01）以及布比卡因 - 吗啡组与布比卡因组之间（P < 0.01）的差异均具有统计学意义。提示骶管注射布比卡因 - 咪达唑仑混合物比布比卡因 - 吗啡混合物和单独使用布比卡因产生的术后镇痛持续时间更长，且术后8 - 12小时有镇静作用。
