Fujii Y, Saitoh Y, Tanaka H, Toyooka H
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.
Eur J Anaesthesiol. 1998 Mar;15(2):166-71.
This study evaluates the prophylactic anti-emetic efficacy of granisetron, droperidol and metoclopramide, for the prevention of post-operative nausea and vomiting in female patients undergoing elective laparoscopic cholecystectomy. The patients were randomly assigned to one of four groups (n = 30 for each group): granisetron 3 mg, droperidol 1.25 mg, metoclopramide 10 mg and placebo (saline). These medications were given immediately before the induction of anaesthesia. During the first 24 h after anaesthesia, the incidence of post-operative nausea and vomiting was 13, 30, 33 and 37% after administration of granisetron, droperidol, metoclopramide and placebo, respectively (P < 0.05, overall Fisher's exact probability test). No clinically important adverse effects were observed in either group. Our results suggest that granisetron is a better anti-emetic than droperidol or metoclopramide for the prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy when compared with a placebo.
本研究评估了格拉司琼、氟哌利多和甲氧氯普胺预防择期腹腔镜胆囊切除术女性患者术后恶心和呕吐的预防性止吐疗效。患者被随机分为四组（每组n = 30）：格拉司琼3毫克、氟哌利多1.25毫克、甲氧氯普胺10毫克和安慰剂（生理盐水）。这些药物在麻醉诱导前立即给予。麻醉后的前24小时内，格拉司琼、氟哌利多、甲氧氯普胺和安慰剂给药后术后恶心和呕吐的发生率分别为13%、30%、33%和37%（P < 0.05，总体Fisher精确概率检验）。两组均未观察到具有临床意义的不良反应。我们的结果表明，与安慰剂相比，格拉司琼在预防腹腔镜胆囊切除术后恶心和呕吐方面比氟哌利多或甲氧氯普胺是更好的止吐药。
