药物代谢酶的基因多态性：日本人CYP2D6和CYP2A6基因中的新突变
Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese.
作者信息
Yokoi T, Kamataki T
机构信息
Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
出版信息
Pharm Res. 1998 Apr;15(4):517-24. doi: 10.1023/a:1011913407147.
Genetic polymorphism of drug metabolizing enzymes, particularly cytochrome P450(CYP), is an important cause of adverse drug reactions. Multiple gene mutations in CYP have been shown to be phenotype. The occurrence of genetic polymorphism has been seen in genes for CYP1A1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A5. This review discusses the molecular mechanism of two genetic polymorphisms, debrisoquine/sparteine (CYP2D6) coumarin (CYP2A6) polymorphisms. In addition, elucidation of gene mutations of CYP2D6 and CYP2A6 in Japanese will be discussed.
药物代谢酶的基因多态性，尤其是细胞色素P450（CYP），是药物不良反应的重要原因。CYP中的多个基因突变已被证明具有表型。在CYP1A1、CYP2A6、CYP2C9、CYP2C19、CYP2D6、CYP2E1和CYP3A5的基因中已发现基因多态性的存在。本综述讨论了两种基因多态性，即异喹胍/鹰爪豆碱（CYP2D6）和香豆素（CYP2A6）多态性的分子机制。此外，还将讨论日本人中CYP2D6和CYP2A6的基因突变情况。
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