Yavorkovsky L L, Carrum G, Bruce S, McCarthy P L
Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.
Am J Hematol. 1998 May;58(1):80-1. doi: 10.1002/(sici)1096-8652(199805)58:1<80::aid-ajh15>3.0.co;2-9.
A patient with Philadelphia-positive (Ph+) chronic myelogenous leukemia (CML) was diagnosed with cutaneous sarcoidosis after treatment with interferon-alpha (IFN-alpha). Following IFN-alpha dose reduction, the skin lesions disappeared. Few cases of sarcoidosis associated with IFN treatment have been reported, and only in one patient with pre-existing CML. Our patient was unique in that (1) the sarcoidosis was induced by the IFN-alpha treatment alone, (2) it developed de novo, and (3) it was confined to the skin.
一名费城染色体阳性（Ph+）慢性粒细胞白血病（CML）患者在接受α干扰素（IFN-α）治疗后被诊断为皮肤结节病。在减少IFN-α剂量后，皮肤病变消失。仅有少数与IFN治疗相关的结节病病例报道，且仅1例患者有CML病史。我们的患者具有独特性，在于（1）结节病仅由IFN-α治疗诱发，（2）为新发疾病，（3）且仅局限于皮肤。
