Dwyer N D, Troemel E R, Sengupta P, Bargmann C I
Howard Hughes Medical Institute, Department of Anatomy, The University of California, San Francisco 94143-0452, USA.
Cell. 1998 May 1;93(3):455-66. doi: 10.1016/s0092-8674(00)81173-3.
Seven transmembrane domain receptors can be localized to different parts of the plasma membrane or to different intracellular compartments in a receptor-specific and cell type-specific fashion. We show here that the C. elegans genes odr-4 and odr-8 are required for localization of a subset of seven transmembrane domain odorant receptors to the cilia of olfactory neurons. Other cilia-signaling proteins, including ion channels, a G alpha protein, and even other receptor types, are localized via an odr-4/odr-8-independent pathway. odr-4 encodes a novel membrane protein that is expressed exclusively on intracellular membranes of chemosensory neurons, where it acts cell-autonomously to facilitate odorant receptor folding or localization.
七跨膜结构域受体能够以受体特异性和细胞类型特异性的方式定位于质膜的不同部位或不同的细胞内区室。我们在此表明，秀丽隐杆线虫基因odr-4和odr-8是七跨膜结构域气味受体的一个亚集定位于嗅觉神经元纤毛所必需的。其他纤毛信号蛋白，包括离子通道、一种Gα蛋白，甚至其他受体类型，是通过一条不依赖odr-4/odr-8的途径进行定位的。odr-4编码一种新的膜蛋白，该蛋白仅在化学感应神经元的细胞内膜上表达，在那里它以细胞自主的方式发挥作用，促进气味受体的折叠或定位。
