Foster D M, Jacquez J A
Am J Physiol. 1978 May;234(5):F402-14. doi: 10.1152/ajprenal.1978.234.5.F402.
The studies presented here use a central core model of the renal medulla, the details of which have been given elsewhere (Foster et al., Mathematical Biosci. 32: 307-335, 337-360, 1976). The central core model of the rabbit medulla predicts concentration gradients and volume flow rates in line with what is known for the rabbit. The handling of urea, however, is not consistent with the scheme proposed by Kokko and Rector (Kidney Intern. 2: 214-233, 1972). Moreover, the low concentration of urea predicted for the urine suggests an absence in the model of some form of mediated transport for urea in the inner medulla. The central core model of the rat medulla failed to predict results consistent with what is known about the rat. Substitution of the rabbit thermodynamic parameters into the model for the rat resulted in predictions that more closely resembled what one might expect, but were not entirely satisfactory. The implication is that there may be an interspecies difference in the concentration machinery between the rabbit and rat.
此处展示的研究使用了肾髓质的核心模型，其细节已在其他地方给出（福斯特等人，《数学生物科学》32: 307 - 335, 337 - 360, 1976）。兔髓质的核心模型预测的浓度梯度和体积流率与兔的已知情况相符。然而，尿素的处理与科科和雷克托提出的方案（《肾脏内科》2: 214 - 233, 1972）不一致。此外，预测的尿液中尿素低浓度表明该模型缺乏髓质内层某种形式的尿素介导转运。大鼠髓质的核心模型未能预测出与大鼠已知情况相符的结果。将兔的热力学参数代入大鼠模型后得到的预测结果更接近预期，但并不完全令人满意。这意味着兔和大鼠之间在浓缩机制上可能存在种间差异。
