Wu C I, Changlai S P, Huang W S, Tsai C H, Lee C C, Kao C H
Divisions of Plastic-Reconstruction Surgery and Hyperbaric Oxygentherapy, China Medical University Hospital, Taichung, Taiwan.
Nucl Med Commun. 2003 Nov;24(11):1185-8. doi: 10.1097/00006231-200311000-00009.
99mTc ethyl cysteinate dimer (99mTc-ECD) brain single photon emission computed tomography (SPECT) was used to detect abnormal regional cerebral blood flow (rCBF) in patients with acute carbon monoxide (CO) poisoning. Ten patients with acute CO poisoning and no past histories of psychoneurological disorders were enrolled in this study. After oxygen treatment, all of the 10 patients were investigated using 99mTc-ECD brain SPECT and brain computed tomography (CT) scan. Brain CT scan findings were normal in all of the 10 patients. 99mTc-ECD brain SPECT showed the hypoperfusion lesions of the basal ganglia and brain cortex in five and seven patients, respectively. Only three of the 10 patients had normal 99mTc-ECD brain SPECT findings. This study suggests that, in comparison with brain CT scan, 99mTc-ECD brain SPECT is a better tool for the early detection of hypoperfusion brain lesions in acute CO poisoning in patients with normal brain CT findings.
采用99m锝-乙半胱氨酸二聚体（99mTc-ECD）脑单光子发射计算机断层扫描（SPECT）检测急性一氧化碳（CO）中毒患者局部脑血流（rCBF）异常。本研究纳入了10例急性CO中毒且无精神神经疾病既往史的患者。经氧疗后，对这10例患者均进行了99mTc-ECD脑SPECT检查及脑部计算机断层扫描（CT）。10例患者的脑部CT扫描结果均正常。99mTc-ECD脑SPECT显示，分别有5例和7例患者的基底节和脑皮质存在灌注不足性病变。10例患者中只有3例的99mTc-ECD脑SPECT结果正常。本研究表明，与脑部CT扫描相比，99mTc-ECD脑SPECT是早期检测脑部CT结果正常的急性CO中毒患者灌注不足性脑病变的更佳工具。
