Kovacs S O
Department of Dermatology, Barnes Hospital, St. Louis, Missouri, USA.
J Am Acad Dermatol. 1998 May;38(5 Pt 1):647-66; quiz 667-8. doi: 10.1016/s0190-9622(98)70194-x.
The destruction of melanocytes is the cause of depigmented maculae that clinically represent the disease vitiligo. Although the cause is unknown, various theories such as the autoimmune, autocytotoxic, and neural hypotheses have been proposed. Extensive research has provided numerous answers regarding the pathogenesis, histopathologic evidence, and treatment of vitiligo. This discussion of vitiligo summarizes the varied clinical presentations of the disease, theories attempting to explain the mechanism of melanocyte destruction, histopathologic findings, and different treatment modalities currently available.
黑素细胞的破坏是临床上表现为白癜风疾病的色素脱失斑的病因。尽管病因不明，但已提出了各种理论，如自身免疫、自身细胞毒性和神经假说。广泛的研究为白癜风的发病机制、组织病理学证据及治疗提供了大量答案。本文对白癜风的讨论总结了该疾病的各种临床表现、试图解释黑素细胞破坏机制的理论、组织病理学发现以及目前可用的不同治疗方式。
