通过定量脑电图评估环丙沙星和芬布芬联合治疗对健康志愿者中枢神经系统的影响。
Assessment of the effects of combination therapy with ciprofloxacin and fenbufen on the central nervous systems of healthy volunteers by quantitative electroencephalography.
作者信息
Kamali F, Ashton C H, Marsh V R, Cox J
机构信息
Wolfson Unit of Clinical Pharmacology, University of Newcastle, Newcastle upon Tyne, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1998 May;42(5):1256-8. doi: 10.1128/AAC.42.5.1256.
Abstract
The potential effects of concurrent administration of fenbufen and ciprofloxacin on central nervous system activity in healthy young subjects were investigated by electroencephalography (EEG). Visual analog scales (VAS) were used to assess subjective measures of concentration, vigilance, tension, and irritability. When ciprofloxacin was administered in combination with fenbufen, none of the EEG parameters or VAS ratings measured were significantly different from those measured when the drugs were administered alone.
摘要
通过脑电图（EEG）研究了在健康年轻受试者中同时服用芬布芬和环丙沙星对中枢神经系统活动的潜在影响。使用视觉模拟量表（VAS）评估注意力、警觉性、紧张感和易怒性的主观指标。当环丙沙星与芬布芬联合使用时，所测量的脑电图参数或VAS评分与单独使用药物时所测量的参数或评分均无显著差异。
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