Effect of intra-arterial infusion of glucose on secretory activity of isolated canine stomach.

Totally isolated stomachs, perfused extracorporeally with homologous blood of living oxygenator dogs, were used for the study of gastric secretion. Pentagastrin or histamine were infused into the gastric artery alone or combined with a 30% solution of glucose. Hyperglycemia was associated with significant inhibition of gastric secretion. Volume, output of HCl and concentration of H+ in gastric secretion were decreased. Hyperglycemia induced also a significant increase in osmotic pressure of gastric secretion and gastric blood. Paired values of H+ and osmotic pressure of gastric secretion were analyzed by the method of least squares, using a computer. The regression line was given by the equation: osmotic pressure (mosm/kg)=311.2-0.167 X [H+] mEq/liter.