Cole S O, Gay P E
Psychopharmacology (Berl). 1976 May 5;47(1):43-7. doi: 10.1007/BF00428699.
A single dose of d-amphetamine (0.25, 0.50, or 1.00 mg/kg), administered in 5 successive sessions, did not seriously impede the discrimination performance of male Holtzman rats under cued reinforcement conditions. A 2.00 mg/kg dose, however, produced a total cessation of operant behavior. In 2 post-drug (saline) sessions, groups previously treated with 0.50 or 1.00 mg/kg demonstrated an initial decrement and subsequent recovery in performance. A second experiment demonstrated that rats administered either saline or 0.50 mg/kg d-amphetamine for 5 successive sessions showed a decrement and subsequent recovery in performance when switched to the opposite treatment condition for the next 2 sessions. These data may be explained in terms of a change in drug state.
在连续5个实验环节中给予单剂量的右旋苯丙胺（0.25、0.50或1.00毫克/千克），并未严重妨碍雄性霍尔兹曼大鼠在线索强化条件下的辨别表现。然而，2.00毫克/千克的剂量导致操作性行为完全停止。在药物注射后（生理盐水）的2个实验环节中，先前接受0.50或1.00毫克/千克剂量的组表现出最初的下降，随后恢复。第二个实验表明，连续5个实验环节给予生理盐水或0.50毫克/千克右旋苯丙胺的大鼠，在接下来的2个实验环节切换到相反的处理条件时，表现出下降并随后恢复。这些数据可以用药物状态的变化来解释。
