Dodick D W, Mosek A C, Campbell J K
Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
Cephalalgia. 1998 Apr;18(3):152-6. doi: 10.1046/j.1468-2982.1998.1803152.x.
Hypnic headache syndrome is a rare, sleep-related, benign headache disorder. We report 19 new cases (84% females) with follow-up data. The mean age at headache onset was 60.5 +/- 9 years (range 40-73 years). Headache awakened the patients from the night's sleep at a consistent time, usually between 1.00 and 3.00 a.m. (63%); three patients (16%) reported that identical headaches could occur also during daytime naps. Headache frequency was high, occurring more than 4 nights/week in 68% of the patients. Headache resolution occurred within 2 h in 68% of patients. Neurologic examination, laboratory studies, and brain imaging were unrevealing at the time of diagnosis. Headache severity largely remains unchanged or attenuates over time, but frequency may vary in either direction. Only one patient had spontaneous relief from headache. Four patients (24%) achieved permanent suppression of headache with medication, and two were able to abort individual headache attacks. Caffeine in a tablet or beverage was helpful in four patients. Lithium carbonate therapy caused side effects requiring cessation of treatment in four patients.
睡眠性头痛综合征是一种罕见的、与睡眠相关的良性头痛疾病。我们报告了19例新病例（84%为女性）并提供随访数据。头痛发作的平均年龄为60.5±9岁（范围40 - 73岁）。头痛通常在夜间固定时间将患者从睡眠中痛醒，通常在凌晨1点至3点之间（63%）；3例患者（16%）报告白天小睡时也会出现同样的头痛。头痛发作频率很高，68%的患者每周发作超过4个晚上。68%的患者头痛在2小时内缓解。诊断时神经系统检查、实验室检查和脑部影像学检查均无异常发现。头痛严重程度在很大程度上随时间保持不变或减轻，但发作频率可能会向任何一个方向变化。只有1例患者头痛自发缓解。4例患者（24%）通过药物治疗实现了头痛的永久缓解，2例能够终止单次头痛发作。片剂或饮料中的咖啡因对4例患者有帮助。碳酸锂治疗导致4例患者出现副作用，需要停止治疗。
