单胺氧化酶B的基因多态性改变了吸烟与帕金森病之间的关联。
A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.
作者信息
Checkoway H, Franklin G M, Costa-Mallen P, Smith-Weller T, Dilley J, Swanson P D, Costa L G
机构信息
Department of Environmental Health, University of Washington, Seattle 98195-7234, USA.
出版信息
Neurology. 1998 May;50(5):1458-61. doi: 10.1212/wnl.50.5.1458.
In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.
在一项基于人群的病例对照研究中，我们发现，就单胺氧化酶B内含子13基因多态性而言，吸烟与帕金森病（PD）之间的关联出现了反转。对于携带G等位基因的人，检测到与吸烟包年数相关的帕金森病风险降低，而在携带A等位基因的人当中则发现了相反的效应。这些结果表明吸烟与这种基因多态性之间存在无法解释的相互作用。
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