Hansen I L, Iwamoto Y, Kishi T, Folkers K, Thompson L E
Res Commun Chem Pathol Pharmacol. 1976 Aug;14(4):729-38.
The specific activities of the succinate dehydrogenase-coenzyme Q10 reductase in mitochondria were determined for patients from a normal periodontal practice. The criteria for selection were patients having a bone score of 1.0-4.0 and a pocket depth of 2.5-5.2 mm. All 29 patients showed a deficiency of 20-63% of CoQ10-enzyme activity in gingival biopsies. The mean value was elevated (P less than 0.001) over that of controls. For corresponding blood samples, 24/28 (86%) showed deficiencies of 20-66% and a higher (P less than 0.001) mean value than that of controls. Periodontal patients frequently have significant gingival and leucocytic deficiencies of CoQ10. The leucocytic deficiency indicates a systemic nutritional imbalance and is not likely caused by neglected oral hygiene. A gingival deficiency could predispose this tissue to periodontitis and this disease could even augment the deficiency. These results support previously suggested adjunctive use of CoQ10 with oral hygiene for improved treatment presumably through bioenergetics.
测定了来自正常牙周科的患者线粒体中琥珀酸脱氢酶 - 辅酶Q10还原酶的比活性。选择标准为骨评分1.0 - 4.0且牙周袋深度2.5 - 5.2毫米的患者。所有29例患者的牙龈活检显示辅酶Q10 - 酶活性缺乏20% - 63%。平均值高于对照组（P < 0.001）。对于相应的血液样本，24/28（86%）显示缺乏20% - 66%，且平均值高于对照组（P < 0.001）。牙周病患者经常存在明显的牙龈和白细胞辅酶Q10缺乏。白细胞缺乏表明全身性营养失衡，不太可能由忽视口腔卫生引起。牙龈缺乏可能使该组织易患牙周炎，而这种疾病甚至可能加剧缺乏。这些结果支持先前提出的辅酶Q10与口腔卫生辅助使用以改善治疗的建议，推测是通过生物能量学实现的。
