Winning A J, Widdicombe J G
Respir Physiol. 1976 Aug;27(2):253-66. doi: 10.1016/0034-5687(76)90078-5.
Tidal volume (VT), and inspiratory (tI) AND EXPIRATORY (TE) durations have been measured in anaesthetized cats on stimulation of alveolar type J (nociceptive) and lung irritant receptors by intravenous injections of phenyl diguanide and of histamine acid phosphate respectively. The reflexes were studied during eupnoea, hypercapnic and hypoxic hyperpnoea, during rebreathing from hyperventilation apnoea and at different body temperatures. In all conditions the drugs caused rapid shallow breathing with reduction in VT, tI and tE. The VT/tI relationship for injection of the drugs was different from that caused by hypercapnic stimulation of breathing, but the tI/tE relationship was proportionally similar for all conditions. Recording single unit activity from phrenic motor fibres showed that the lung reflexes had little action on the initial frequency of discharge of the fibres, but cut short the discharge earlier than for the controls. The results are interpreted in terms of the ways in which lung reflexes can modify the pattern of breathing.
分别通过静脉注射苯基双胍和磷酸组胺酸刺激麻醉猫的肺泡J型（伤害性）和肺刺激性受体，测量了潮气量（VT）、吸气（tI）和呼气（TE）持续时间。在平静呼吸、高碳酸血症和低氧性深呼吸、过度通气性呼吸暂停再呼吸期间以及不同体温下研究了这些反射。在所有情况下，这些药物都会导致呼吸浅快，VT、tI和tE均降低。注射药物时的VT/tI关系与高碳酸血症刺激呼吸所引起的关系不同，但在所有情况下，tI/tE关系成比例相似。记录膈运动纤维的单单位活动表明，肺反射对纤维放电的初始频率作用很小，但比对照组更早地缩短了放电时间。根据肺反射改变呼吸模式的方式对结果进行了解释。
