Levy I, Rubin L G, Vasishtha S, Tucci V, Sood S K
Division of Pediatric Infectious Diseases, Schneider Children's Hospital, New Hyde Park, New York 11040, USA.
Clin Infect Dis. 1998 May;26(5):1086-8. doi: 10.1086/520277.
An increase in the rate of isolation of Candida parapsilosis, relative to other Candida species, in our children's hospital led us to analyze the clinical and epidemiological variables associated with candidemia. We sought to determine if these variables are different for patients infected with C. parapsilosis. All episodes of candidemia occurring over a 7-year period were analyzed retrospectively. Of 81 episodes in 80 patients, 35 (43%) were in neonates, and 46 (57%) were in nonneonates. C. parapsilosis was isolated in 40 episodes (49%). C. parapsilosis was significantly more likely than non-C. parapsilosis species to be associated with prematurity (P = .001), presence of a central venous catheter (P = .002), and use of total parenteral nutrition (P = .03). C. parapsilosis has emerged as the predominant species in our children's hospital. The mortality rate associated with candidemia in children is lower than previously reported and may be associated with the high rate of isolation of C. parapsilosis.
在我们儿童医院，近平滑念珠菌的分离率相对于其他念珠菌属有所增加，这促使我们分析与念珠菌血症相关的临床和流行病学变量。我们试图确定这些变量对于感染近平滑念珠菌的患者是否有所不同。对7年期间发生的所有念珠菌血症病例进行了回顾性分析。80例患者的81次感染发作中，35例（43%）为新生儿，46例（57%）为非新生儿。40次发作（49%）分离出近平滑念珠菌。近平滑念珠菌与非近平滑念珠菌属相比，与早产（P = .001）、存在中心静脉导管（P = .002）和使用全胃肠外营养（P = .03）的相关性显著更高。近平滑念珠菌已成为我们儿童医院的主要菌种。儿童念珠菌血症的死亡率低于先前报道，可能与近平滑念珠菌的高分离率有关。
