Petit-Taboué M C, Landeau B, Desson J F, Desgranges B, Baron J C
INSERM U320, Cyceron, CEA DSV/DRM, Université de Caen, France.
Neuroimage. 1998 Apr;7(3):176-84. doi: 10.1006/nimg.1997.0318.
The aging process is thought to result in changes in synaptic activity reflecting both functional and structural cell derangement. However, previous PET reports on age-related changes in resting brain glucose utilization (CMRglc) have been discrepant, presumably because of methodological as well as subject screening differences. In contrast to other studies, which used a region of interest approach, the objective of the present work was to determine, by means of the SPM software, the changes in regional CMRglc as a function of age in 24 optimally healthy, unmedicated volunteers of ages from 20 to 67 years. Global CMRglc showed a significant decline with age (approximately 6% per decade, P < 0.05), which concerned all the voxels studied save for most of the occipital cortex and part of the cerebellum. The most significant effects (P < 0.001) concerned the association neocortex in perisylvian temporoparietal and anterior temporal areas, the insula, the inferior and posterior-lateral frontal regions, the anterior cingulate cortex, the head of caudate nucleus, and the anterior thalamus, in a bilateral and essentially symmetrical fashion. The high posterior parietal cortex was not sampled in this study. This distribution of changes in CMRglc with age may differ from that seen in Alzheimer' disease, where the earliest metabolic reduction has been shown to affect the posterior cingulate cortex.
衰老过程被认为会导致突触活动发生变化，这反映了细胞功能和结构的紊乱。然而，先前关于静息脑葡萄糖利用（CMRglc）与年龄相关变化的PET报告存在差异，推测是由于方法学以及受试者筛选的差异。与其他采用感兴趣区域方法的研究不同，本研究的目的是通过SPM软件确定24名年龄在20至67岁之间、健康状况最佳且未服用药物的志愿者中，区域CMRglc随年龄变化的情况。整体CMRglc随年龄显著下降（每十年约6%，P < 0.05），除了大部分枕叶皮质和部分小脑外，所有研究的体素均呈现这种情况。最显著的影响（P < 0.001）涉及颞顶叶和颞前叶周缘的联合新皮质、脑岛、额下和额后外侧区域、前扣带回皮质、尾状核头部以及丘脑前部，呈双侧且基本对称的方式。本研究未对顶叶后上部皮质进行采样。CMRglc随年龄变化的这种分布可能与阿尔茨海默病不同，在阿尔茨海默病中，最早的代谢降低已被证明会影响后扣带回皮质。
