Holmquist G P, Comings D E
Science. 1976 Aug 13;193(4253):599-602. doi: 10.1126/science.959822.
Polylysine, polyarginine, and histones H1, H2A, H2B, and H3 inhibit Giemsa staining and chromosome banding by binding to DNA and preventing side stacking of the positively charged thiazine dyes to the negatively charged phosphate groups on DNA. This is a nonspecific effect and does not of itself provide evidence for a role of histones in G banding. The question of whether histones are involved in chromosome banding is reviewed.
聚赖氨酸、聚精氨酸以及组蛋白H1、H2A、H2B和H3通过与DNA结合并阻止带正电荷的噻嗪染料与DNA上带负电荷的磷酸基团进行侧面堆积，从而抑制吉姆萨染色和染色体显带。这是一种非特异性效应，其本身并不能为组蛋白在G显带中的作用提供证据。本文对组蛋白是否参与染色体显带这一问题进行了综述。
