Vaccari T, Beltrame M, Ferrari S, Bianchi M E
DIBIT, San Raffaele Scientific Institute, Milan, Italy.
Genomics. 1998 Apr 15;49(2):247-52. doi: 10.1006/geno.1998.5214.
High mobility group (HMG) proteins are abundant components of mammalian nuclei and fall into three families. The members of one such family, HMG1 and HMG2, are ubiquitously expressed and facilitate the formation of nucleoprotein complexes where the DNA is sharply bent. We have identified a mouse cDNA that codes for a novel 200-amino-acid protein of the HMG1/2 family, which we called HMG4. The mouse Hmg4 gene is highly expressed in the embryo; Hmg4 transcripts are barely detectable in adult tissues. The human HMG4 gene, which is extremely similar to its mouse homolog, has been sequenced as part of chromosome X, band q28. HMG4, HMG1, and HMG2 proteins have been highly conserved during vertebrate evolution, suggesting that each has at least some unique property. It is possible that HMG4 is required during development.
高迁移率族（HMG）蛋白是哺乳动物细胞核中的丰富成分，可分为三个家族。其中一个家族的成员HMG1和HMG2在全身广泛表达，并促进DNA急剧弯曲的核蛋白复合物的形成。我们鉴定出一个小鼠cDNA，它编码HMG1/2家族的一种新型200个氨基酸的蛋白质，我们将其称为HMG4。小鼠Hmg4基因在胚胎中高度表达；在成年组织中几乎检测不到Hmg4转录本。人类HMG4基因与其小鼠同源物极为相似，已作为X染色体q28带的一部分进行了测序。HMG4、HMG1和HMG2蛋白在脊椎动物进化过程中高度保守，这表明它们各自至少具有一些独特的特性。HMG4在发育过程中可能是必需的。
