Plazzi G, Cortelli P, Montagna P, De Monte A, Corsini R, Contin M, Provini F, Pierangeli G, Lugaresi E
Institute of Clinical Neurology, University of Bologna, Italy.
J Neurol Neurosurg Psychiatry. 1998 May;64(5):683-5. doi: 10.1136/jnnp.64.5.683.
Ten patients with primary autonomic failure, followed up in a prospective clinical and laboratory study, were finally diagnosed as pure autonomic failure or multiple system atrophy with autonomic failure. Polysomnographic studies were performed in all patients. Whereas all four patients with multiple system atrophy complained of sleep related episodes suggesting REM sleep behaviour disorder (RBD) confirmed by polysomnography, RBD remained absent in the remaining six patients with pure autonomic failure. The data indicate that RBD is an important clinical feature, often heralding multiple system atrophy, but which is absent throughout the course of pure autonomic failure; its recognition can thus be useful in the prognostic evaluation of early primary autonomic failure syndromes.
在一项前瞻性临床和实验室研究中对10例原发性自主神经功能衰竭患者进行随访，最终诊断为单纯自主神经功能衰竭或合并自主神经功能衰竭的多系统萎缩。所有患者均进行了多导睡眠图研究。4例多系统萎缩患者均主诉有与睡眠相关的发作，提示快速眼动睡眠行为障碍（RBD），多导睡眠图证实了这一点，而其余6例单纯自主神经功能衰竭患者未出现RBD。数据表明，RBD是一个重要的临床特征，常预示多系统萎缩，但在单纯自主神经功能衰竭病程中始终不存在；因此，识别RBD有助于早期原发性自主神经功能衰竭综合征的预后评估。
