抑制动脉壁中前列环素（PGI2）的合成会增强体内白色血小板血栓的形成。
Inhibition of PGI2 (prostacyclin) synthesis in the arterial wall enhances the formation of white platelet thrombi in vivo.
作者信息
Bourgain R H
出版信息
Haemostasis. 1978;7(4):252-5. doi: 10.1159/000214266.
PMID:95991
Abstract
Prostaglandins play an important role in platelet-vessel wall interactions. Cyclic endoperoxides PGG2 and PGH2 are transformed to PGI2 (prostacyclin) within the arterial wall. The inhibition of PGI2 synthetase results in a marked enhancement of white platelet thrombus formations. This finding suggests that the synthesis of PGI2 from PGG2 and PGH2 accounts for the nonthrombogenicity of the endothelium.
摘要
前列腺素在血小板与血管壁的相互作用中起重要作用。环内过氧化物PGG2和PGH2在动脉壁内转化为PGI2（前列环素）。抑制PGI2合成酶会导致白色血小板血栓形成显著增强。这一发现表明，从PGG2和PGH2合成PGI2是内皮具有抗血栓形成特性的原因。
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引用本文的文献
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Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin.第八届加德姆纪念讲座。1980年12月于伦敦大学教育学院。前列环素的生物学重要性。
Br J Pharmacol. 1982 May;76(1):3-31. doi: 10.1111/j.1476-5381.1982.tb09186.x.
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Arachidonic acid and prostaglandin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated and cultivated coronary microvessel endothelial cells.花生四烯酸和前列腺素内过氧化物在离体兔冠状动脉微血管以及离体培养的冠状动脉微血管内皮细胞中的代谢
J Clin Invest. 1983 Nov;72(5):1658-71. doi: 10.1172/JCI111125.
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