从台湾柳珊瑚Briareum excavatum中分离得到的新型细胞毒性二萜类化合物，excavatolides A - E。

Novel cytotoxic diterpenes, excavatolides A-E, isolated from the Formosan gorgonian Briareum excavatum.

作者信息

Sheu J H, Sung P J, Cheng M C, Liu H Y, Fang L S, Duh C Y, Chiang M Y

机构信息

Department of Marine Resources and Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China.

出版信息

J Nat Prod. 1998 May;61(5):602-8. doi: 10.1021/np970553w.

DOI:10.1021/np970553w

PMID:9599257

Abstract

The chemistry of Briareum excavatum, a Formosan gorgonian coral, was investigated. This study has led to the isolation of five novel marine natural products, excavatolides A-E (1-5), together with brianolide (6). The structures of the above compounds were established by spectral and chemical methods. The relative configuration of excavatolide B (2) was further confirmed by a single-crystal X-ray structure analysis. Cytotoxicity of these compounds toward various cancer cell lines also is described.

摘要

对台湾柳珊瑚Briareum excavatum的化学性质进行了研究。该研究已分离出五种新型海洋天然产物，即掘海绵内酯A - E（1 - 5），以及布氏内酯（6）。上述化合物的结构通过光谱和化学方法确定。掘海绵内酯B（2）的相对构型通过单晶X射线结构分析进一步得到证实。还描述了这些化合物对各种癌细胞系的细胞毒性。