来自台湾软珊瑚伞花柳珊瑚的新型细胞毒性异株二萜类化合物。

New cytotoxic xenia diterpenoids from the Formosan soft coral Xenia umbellata.

作者信息

Duh Chang-Yih, El-Gamal Ali Ali H, Chiang Chin-Ying, Chu Chih-Ju, Wang Shang-Kwei, Dai Chang-Feng

机构信息

Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.

出版信息

J Nat Prod. 2002 Dec;65(12):1882-5. doi: 10.1021/np020268z.

DOI:10.1021/np020268z

PMID:12502332

Abstract

Seven new cytotoxic xenicane-type diterpenoids, 9-deoxyxeniloide-E (1), 9-deoxy-7,8-epoxyxeniloide-E (2), xeniolide-G (3), 9-deoxyxenialactol-C (4), xenibecin (5), xeniolide-H (6), and xenitacin (7), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia umbellata. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

摘要

从台湾软珊瑚伞花柳珊瑚（Xenia umbellata）的二氯甲烷可溶物中分离出七种新的具有细胞毒性的异海松烷型二萜类化合物，9-脱氧异海松内酯-E（1）、9-脱氧-7,8-环氧异海松内酯-E（2）、异海松内酯-G（3）、9-脱氧异海松内酯醇-C（4）、柳珊瑚素（5）、异海松内酯-H（6）和柳珊瑚他星（7）。通过一维和二维核磁共振光谱分析阐明了它们的结构，并在体外测定了它们对选定癌细胞的细胞毒性。