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举个例子。关于激素替代疗法的咨询。

Case in point. Counseling about hormone replacement therapy.

作者信息

Mahon S M

机构信息

Cancer Screening Center, Deaconess Health System, St. Louis, MO, USA.

出版信息

Oncol Nurs Forum. 1998 May;25(4):663-4.

PMID:9599344
Abstract

Mrs. S's case demonstrates the dilemmas that many women face at menopause regarding HRT. No clear answer to her question exists. Oncology nurses need to help women understand that taking HRT is a decision that is best made after carefully weighing the risks and benefits of therapy. Mrs. S needs to realize that she has some risk factors for heart disease, osteoporosis, breast cancer, and uterine cancer. Depending on her motivation, Mrs. S can modify some of the risk factors (e.g., reducing her weight and cholesterol). Smoking cessation also would reduce her risk for heart disease and, to a lesser extent, osteoporosis. Although her risk for developing breast cancer is higher than for a woman without a family history of breast cancer, she only has one relative who was older when she developed breast cancer. This risk factor in itself probably would not be enough to advise her against taking HRT. Additional testing may offer some clarification. If her breasts are difficult to examine or her mammograms are difficult to interpret, Mrs. S may feel that the risk of missing breast cancer early is too high to justify taking HRT. An abnormal endometrial biopsy also may make Mrs. S decide against taking HRT. BMD testing might help to better assess her risk for osteoporosis. If some bone loss has occurred before menopause, she may want to give more consideration to taking HRT or medications such as alendronate sodium to reduce her risk for an osteoporotic fracture. Women need to understand that, often, no best answer is available to the question of whether or not to take HRT. With every decision comes some consequences. An understanding of risk factors and ways to maximize cardiovascular, breast, endometrial, and bone health are important factors to consider when making an informed decision. Clearly, this is an area where oncology nurses can provide tremendous patient education and support to women making decisions about HRT.

摘要

S女士的病例展现了许多女性在更年期面对激素替代疗法(HRT)时所面临的困境。对于她的问题,目前尚无明确答案。肿瘤护理人员需要帮助女性明白,使用HRT是一个最好在仔细权衡治疗风险和益处后再做的决定。S女士需要意识到她存在一些患心脏病、骨质疏松症、乳腺癌和子宫癌的风险因素。根据她的动机,S女士可以改变一些风险因素(例如,减轻体重和降低胆固醇)。戒烟也会降低她患心脏病的风险,在较小程度上还能降低患骨质疏松症的风险。虽然她患乳腺癌的风险高于没有乳腺癌家族史的女性,但她只有一位亲属在患乳腺癌时年龄较大。仅这一风险因素本身可能不足以建议她不使用HRT。进一步的检查可能会提供一些更清晰的情况。如果她的乳房难以检查或她的乳房X光片难以解读,S女士可能会觉得早期漏诊乳腺癌的风险过高,以至于使用HRT不合理。子宫内膜活检结果异常也可能使S女士决定不使用HRT。骨密度测试可能有助于更好地评估她患骨质疏松症的风险。如果在绝经前就已经出现了一些骨质流失,她可能会更倾向于考虑使用HRT或服用阿仑膦酸钠等药物来降低患骨质疏松性骨折的风险。女性需要明白,对于是否使用HRT这个问题,通常没有最佳答案。每一个决定都会带来一些后果。了解风险因素以及使心血管、乳房、子宫内膜和骨骼健康最大化的方法,是做出明智决定时需要考虑的重要因素。显然,在这方面肿瘤护理人员可以为正在就HRT做出决定的女性提供大量的患者教育和支持。

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