Mori A, Noda Y, Packer L
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.
Epilepsy Res. 1998 Apr;30(2):153-8. doi: 10.1016/s0920-1211(97)00097-1.
Zonisamide (ZNS) is effective in animal models of epilepsy and epileptic patients. The free radical scavenging activities of ZNS were analyzed by using electron spin resonance. ZNS, in the mmolar range, scavenged hydroxyl and nitric oxide radicals in a dose-dependent manner. This suggests that the mechanism of antiepileptic effect of ZNS may involve protection of neurons from free radical damage and stabilization of neuronal membranes.
唑尼沙胺（ZNS）在癫痫动物模型和癫痫患者中均有效。通过电子自旋共振分析了唑尼沙胺的自由基清除活性。在毫摩尔范围内，唑尼沙胺以剂量依赖性方式清除羟基自由基和一氧化氮自由基。这表明唑尼沙胺的抗癫痫作用机制可能涉及保护神经元免受自由基损伤以及稳定神经细胞膜。
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