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减肥手术对糖尿病与肥胖症合并症患者新陈代谢的影响:近期研究洞察

Effect of bariatric surgery on metabolism in diabetes and obesity comorbidity: Insight from recent research.

作者信息

Tang Hui-Hong, Wang Dong, Tang Cheng-Chun

机构信息

Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu Province, China.

School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China.

出版信息

World J Diabetes. 2024 Apr 15;15(4):586-590. doi: 10.4239/wjd.v15.i4.586.

DOI:10.4239/wjd.v15.i4.586
PMID:38680688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11045418/
Abstract

Obesity is a prevalent cause of diabetes mellitus (DM) and is a serious danger to human health. Type 2 DM (T2DM) mostly occurs along with obesity. Foodborne obesity-induced DM is caused by an excessive long-term diet and surplus energy. Bariatric surgery can improve the symptoms of T2DM in some obese patients. But different types of bariatric surgery may have different effects. There are some models built by researchers to discuss the surgical procedures' effects on metabolism in diabetes animal models and diabetes patients. It is high time to conclude all this effects and recommend procedures that can better improve metabolism.

摘要

肥胖是糖尿病(DM)的常见病因,对人类健康构成严重威胁。2型糖尿病(T2DM)大多与肥胖同时发生。食物源性肥胖诱导的糖尿病是由长期过度饮食和能量过剩引起的。减重手术可以改善一些肥胖患者的T2DM症状。但不同类型的减重手术可能有不同的效果。研究人员建立了一些模型来探讨手术程序对糖尿病动物模型和糖尿病患者新陈代谢的影响。现在是时候总结所有这些影响并推荐能够更好地改善新陈代谢的手术程序了。

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Effect of bariatric surgery on metabolism in diabetes and obesity comorbidity: Insight from recent research.减肥手术对糖尿病与肥胖症合并症患者新陈代谢的影响:近期研究洞察
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本文引用的文献

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The Role of Pancreatic Fatty Acid Synthesis in Islet Morphology and Function after Caloric Restriction or Roux-En-Y Gastric Bypass Surgery in Mice.热量限制或 Roux-en-Y 胃旁路手术后胰腺脂肪酸合成在小鼠胰岛形态和功能中的作用。
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Intravital imaging of islet Ca dynamics reveals enhanced β cell connectivity after bariatric surgery in mice.活体成像检测胰岛钙动力学变化揭示了减肥手术后小鼠β细胞连接增强。
Nat Commun. 2021 Aug 27;12(1):5165. doi: 10.1038/s41467-021-25423-8.
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Characterization of the renal cortical transcriptome following Roux-en-Y gastric bypass surgery in experimental diabetic kidney disease.实验性糖尿病肾病中Roux-en-Y胃旁路手术后肾皮质转录组的特征分析
BMJ Open Diabetes Res Care. 2020 Jul;8(1). doi: 10.1136/bmjdrc-2019-001113.
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A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.Roux-en-Y 胃旁路术(肠胃吻合术)的替代物在 ob/ob 小鼠糖尿病缓解过程中调节多种β细胞通路。
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Sleeve Gastrectomy Attenuates Diabetic Nephropathy by Upregulating Nephrin Expressions in Diabetic Obese Rats.袖状胃切除术通过上调糖尿病肥胖大鼠的nephrin 表达来减轻糖尿病肾病。
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9
Jejunal long noncoding RNAs are associated with glycemic control via gut-brain axis after bariatric surgery in diabetic mice.空肠长链非编码 RNA 通过肥胖症手术后的肠道-大脑轴与糖尿病小鼠的血糖控制相关。
Surg Obes Relat Dis. 2018 Jun;14(6):821-832. doi: 10.1016/j.soard.2018.03.006. Epub 2018 Mar 9.
10
Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities.减肥手术与药物性肥胖治疗与长期医学并发症及肥胖相关合并症的关联
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