人体小梁骨中1H→31P交叉极化的动力学

Kinetics of 1H --> 31P cross-polarization in human trabecular bone.

作者信息

Kaflak A, Chmielewski D, Górecki A, Kolodziejski W

机构信息

Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, Warszawa, Poland.

出版信息

Solid State Nucl Magn Reson. 1998 Feb;10(4):191-5. doi: 10.1016/s0926-2040(97)00085-4.

DOI:10.1016/s0926-2040(97)00085-4

PMID:9603619

Abstract

Bloch-decay and cross-polarization (CP) 31P nuclear magnetic resonance (NMR) spectra of healthy human trabecular bone were acquired under magic-angle spinning (MAS) at 3 kHz. A single peak at 3.1 ppm was detected. Variable-contact time 1H --> 31P CP experiments revealed three signal components growing at various rates. The fast, moderate and slow components were assigned and assessed in P atom % to proton-rich (24%), hydroxyapatite (58%) and proton-deficient (18%) phosphate domains, respectively. Examination of CP kinetics is useful for the chemical characterization of bone tissue.

摘要

在3 kHz的魔角旋转（MAS）条件下，采集了健康人松质骨的布洛赫衰减和交叉极化（CP）31P核磁共振（NMR）谱。检测到3.1 ppm处有一个单峰。可变接触时间的1H→31P CP实验揭示了三个以不同速率增长的信号成分。快速、中等和慢速成分分别对应富含质子（24%）、羟基磷灰石（58%）和质子缺乏（18%）的磷酸盐区域，并以磷原子百分比进行了赋值和评估。CP动力学研究有助于骨组织的化学表征。