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本文引用的文献

1
Arac/XylS family of transcriptional regulators.Arac/XylS转录调节因子家族。
Microbiol Mol Biol Rev. 1997 Dec;61(4):393-410. doi: 10.1128/mmbr.61.4.393-410.1997.
2
Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.染色体介导的多重抗生素耐药性调控：mar操纵子
Antimicrob Agents Chemother. 1997 Oct;41(10):2067-75. doi: 10.1128/AAC.41.10.2067.
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Characterization of a porin from Mycobacterium smegmatis.耻垢分枝杆菌孔蛋白的特性分析
J Bacteriol. 1997 Oct;179(19):6205-7. doi: 10.1128/jb.179.19.6205-6207.1997.
4
Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter family.结核分枝杆菌efpA编码一种QacA转运蛋白家族的外排蛋白。
Clin Diagn Lab Immunol. 1997 Jan;4(1):23-32. doi: 10.1128/cdli.4.1.23-32.1997.
5
The TACAN4TGCA motif upstream from the -35 region in the sigma70-sigmaS-dependent Pm promoter of the TOL plasmid is the minimum DNA segment required for transcription stimulation by XylS regulators.在TOL质粒的sigma70-sigmaS依赖性Pm启动子中，-35区域上游的TACAN4TGCA基序是XylS调节因子刺激转录所需的最小DNA片段。
J Bacteriol. 1996 Nov;178(22):6427-34. doi: 10.1128/jb.178.22.6427-6434.1996.
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Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump.耻垢分枝杆菌中由多药外排泵LfrA介导的氟喹诺酮类药物主动外排
J Bacteriol. 1996 Jul;178(13):3791-5. doi: 10.1128/jb.178.13.3791-3795.1996.
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An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae.结核分枝杆菌H37Rv的基因组整合图谱以及与麻风分枝杆菌的比较。
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3132-7. doi: 10.1073/pnas.93.7.3132.
8
Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli.大肠杆菌多重抗生素耐药性（mar）位点的遗传与功能分析
J Bacteriol. 1993 Mar;175(5):1484-92. doi: 10.1128/jb.175.5.1484-1492.1993.
9
SoxS, an activator of superoxide stress genes in Escherichia coli. Purification and interaction with DNA.SoxS，大肠杆菌中超氧化物应激基因的激活剂。纯化及其与DNA的相互作用。
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A simple procedure for gel electrophoresis and northern blotting of RNA.一种用于RNA凝胶电泳和Northern印迹的简单方法。
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耻垢分枝杆菌中大肠杆菌marA基因表达后的多药耐药性。

Multidrug resistance following expression of the Escherichia coli marA gene in Mycobacterium smegmatis.

作者信息

McDermott P F, White D G, Podglajen I, Alekshun M N, Levy S B

机构信息

Center for Adaptation Genetics and Drug Resistance and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

出版信息

J Bacteriol. 1998 Jun;180(11):2995-8. doi: 10.1128/JB.180.11.2995-2998.1998.

DOI:10.1128/JB.180.11.2995-2998.1998
PMID:9603894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC107271/
Abstract

Expression of the Escherichia coli multiple antibiotic resistance marA gene cloned in Mycobacterium smegmatis produced increased resistance to multiple antimicrobial agents, including rifampin, isoniazid, ethambutol, tetracycline, and chloramphenicol. Cloned marR or marA cloned in the antisense direction had no effect. Resistance changes were lost with spontaneous loss of the plasmid bearing marA. A MarA mutant protein, having an insertional mutation within either of its two alpha-helices of the first putative helix-turn-helix domain, failed to produce the multiresistance phenotype in E. coli and M. smegmatis, indicating that this region is critical for MarA function. These results strongly suggest that E. coli marA functions in M. smegmatis and that a mar-like regulatory system exists in this organism.

摘要

克隆于耻垢分枝杆菌中的大肠杆菌多重抗生素耐药性marA基因的表达，使耻垢分枝杆菌对多种抗菌剂产生了更高的耐药性，这些抗菌剂包括利福平、异烟肼、乙胺丁醇、四环素和氯霉素。以反义方向克隆的marR或marA没有效果。随着携带marA的质粒自发丢失，耐药性变化也消失了。在第一个假定的螺旋-转角-螺旋结构域的两个α-螺旋中的任何一个内发生插入突变的MarA突变蛋白，在大肠杆菌和耻垢分枝杆菌中均未能产生多耐药表型，这表明该区域对MarA功能至关重要。这些结果有力地表明，大肠杆菌marA在耻垢分枝杆菌中发挥作用，并且该生物体中存在类似mar的调控系统。