Carlson S A, Frana T S, Griffith R W
Preharvest Food Safety and Enteric Disease Research Unit, National Animal Disease Center, U.S. Department of Agriculture Agricultural Research Service, Ames, Iowa 50010, USA.
Appl Environ Microbiol. 2001 Aug;67(8):3763-6. doi: 10.1128/AEM.67.8.3763-3766.2001.
Microcin 24 is an antimicrobial peptide secreted by uropathogenic Escherichia coli. Secretion of microcin 24 provides an antibacterial defense mechanism for E. coli. In a plasmid-based system using transformed Salmonella enterica, we found that resistance to microcin 24 could be seen in concert with a multiple-antibiotic resistance phenotype. This multidrug-resistant phenotype appeared when Salmonella was exposed to an E. coli strain expressing microcin 24. Therefore, it appears that multidrug-resistant Salmonella can arise as a result of an insult from other pathogenic bacteria.
微菌素24是一种由尿路致病性大肠杆菌分泌的抗菌肽。微菌素24的分泌为大肠杆菌提供了一种抗菌防御机制。在一个使用转化的肠炎沙门氏菌的基于质粒的系统中，我们发现对微菌素24的抗性可能与多重抗生素抗性表型同时出现。当沙门氏菌暴露于表达微菌素24的大肠杆菌菌株时，就会出现这种多药耐药表型。因此，看来多药耐药沙门氏菌可能是由于受到其他病原菌的侵害而产生的。
