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本文引用的文献

1
Autoactivation and environmental regulation of bfpT expression, the gene coding for the transcriptional activator of bfpA in enteropathogenic Escherichia coli.肠致病性大肠杆菌中bfpA转录激活因子编码基因bfpT的自激活及环境调控
Mol Microbiol. 1999 Jul;33(1):153-66. doi: 10.1046/j.1365-2958.1999.01460.x.
2
Transcriptional control of genes encoding CS1 pili: negative regulation by a silencer and positive regulation by Rns.编码CS1菌毛的基因的转录调控：由一个沉默子进行负调控以及由Rns进行正调控。
J Bacteriol. 1997 Sep;179(18):5736-43. doi: 10.1128/jb.179.18.5736-5743.1997.
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Interactions between enteropathogenic Escherichia coli and host epithelial cells.肠道致病性大肠杆菌与宿主上皮细胞之间的相互作用。
Trends Microbiol. 1997 Mar;5(3):109-14. doi: 10.1016/S0966-842X(97)01000-7.
4
BfpB, an outer membrane lipoprotein required for the biogenesis of bundle-forming pili in enteropathogenic Escherichia coli.BfpB是肠道致病性大肠杆菌中形成束状菌毛生物合成所必需的一种外膜脂蛋白。
J Bacteriol. 1996 Nov;178(22):6555-63. doi: 10.1128/jb.178.22.6555-6563.1996.
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Cloning and characterization of bfpTVW, genes required for the transcriptional activation of bfpA in enteropathogenic Escherichia coli.肠致病性大肠杆菌中bfpA转录激活所需基因bfpTVW的克隆与特性分析
Mol Microbiol. 1996 Sep;21(5):963-75. doi: 10.1046/j.1365-2958.1996.531415.x.
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The bundle-forming pili of enteropathogenic Escherichia coli: transcriptional regulation by environmental signals.肠道致病性大肠杆菌的束状菌毛：环境信号的转录调控
Mol Microbiol. 1996 Apr;20(1):87-100. doi: 10.1111/j.1365-2958.1996.tb02491.x.
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A cluster of fourteen genes from enteropathogenic Escherichia coli is sufficient for the biogenesis of a type IV pilus.来自肠致病性大肠杆菌的一组14个基因足以实现IV型菌毛的生物合成。
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Enteropathogenic Escherichia coli: identification of a gene cluster coding for bundle-forming pilus morphogenesis.肠致病性大肠杆菌：编码束状菌毛形态发生的基因簇的鉴定
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A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase.细菌启动子中的第三种识别元件：RNA聚合酶α亚基与DNA的结合。
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Cloning and characterization of the bundle-forming pilin gene of enteropathogenic Escherichia coli and its distribution in Salmonella serotypes.肠致病性大肠杆菌成束菌毛菌素基因的克隆、特性分析及其在沙门氏菌血清型中的分布
Mol Microbiol. 1993 Feb;7(4):563-75. doi: 10.1111/j.1365-2958.1993.tb01147.x.

肠致病性大肠杆菌中bfpA表达所需顺式作用元件的分析

Analysis of cis-acting elements required for bfpA expression in enteropathogenic Escherichia coli.

作者信息

Bustamante V H, Calva E, Puente J L

机构信息

Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62250, Mexico.

出版信息

J Bacteriol. 1998 Jun;180(11):3013-6. doi: 10.1128/JB.180.11.3013-3016.1998.

DOI:10.1128/JB.180.11.3013-3016.1998
PMID:9603898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC107275/
Abstract

bfpA expression in enteropathogenic Escherichia coli is regulated by growth medium, temperature, and ammonium concentration and requires the BfpT protein (also called PerA), a member of the AraC family of transcriptional activators. Site-directed and PCR random mutagenesis, as well as deletion analysis of the bfpA upstream regulatory region, supported assignment of the promoter elements and demonstrated that the cis-acting elements that mediate BfpT-dependent regulation of bfpA are located between positions -85 and -46. Interestingly, this region shares 73% identity with a 40-bp-long AT-rich tract located upstream of the bfpT gene, which is essential for bfpT autoregulation.

摘要

肠道致病性大肠杆菌中bfpA的表达受生长培养基、温度和铵浓度的调节，并且需要BfpT蛋白（也称为PerA），它是转录激活因子AraC家族的成员。定点诱变和PCR随机诱变，以及bfpA上游调控区的缺失分析，支持了启动子元件的定位，并证明介导bfpA的BfpT依赖性调控的顺式作用元件位于-85至-46位之间。有趣的是，该区域与位于bfpT基因上游的一段40bp长的富含AT的序列有73%的同一性，这对于bfpT的自我调节至关重要。