Bryant-Greenwood P K, O'Brien J E, Huang X, Yaron Y, Ayoub M, Johnson M P, Evans M I
Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, Mich 48201, USA.
Fetal Diagn Ther. 1998 Jan-Feb;13(1):46-8. doi: 10.1159/000020801.
In previous work, we and others have shown that serum levels of alpha-fetoprotein, human chorionic gonadotropin, and estriol vary among the four commonly defined racial/ethnic groups seen in the United States: white, African-American, Asian, and Hispanic. We have suggested that better sensitivity and specificity could improve screening sensitivity and specificity. However, it has been argued that systematic weight differences among the groups could explain the variation. We evaluated the results from 208,257 patients having screening and found systematic weight differences. However, these differences were not as large as the racial/ethnic differences, showing that weight does not fully explain the discrepancy, and, therefore, four separate data bases give more accurate results.
在之前的研究中，我们和其他研究人员已经表明，在美国常见的四个种族/族裔群体（白人、非裔美国人、亚裔和西班牙裔）中，甲胎蛋白、人绒毛膜促性腺激素和雌三醇的血清水平存在差异。我们曾提出，更高的敏感性和特异性可以提高筛查的敏感性和特异性。然而，有人认为群体之间的系统性体重差异可以解释这种变化。我们评估了208,257名接受筛查患者的结果，发现了系统性体重差异。然而，这些差异并没有种族/族裔差异那么大，这表明体重并不能完全解释这种差异，因此，四个单独的数据库能给出更准确的结果。
