Kakkanaiah V N, Shen G Q, Ojo-Amaize E A, Peter J B
Specialty Laboratories, Santa Monica, California 90404-3900, USA.
Clin Diagn Lab Immunol. 1998 May;5(3):319-21. doi: 10.1128/CDLI.5.3.319-321.1998.
Low concentrations of mannose-binding protein (MBP; also known as mannose-binding lectin) are associated with common opsonic defect in immunodeficient children. We compared the concentrations of MBP in the sera of 47 adults with non-human immunodeficiency virus-related recurrent infections (group I) and 50 healthy adult controls. Mean serum MBP concentrations in the patient group did not differ significantly from those in the control group (P < 0.4). Nevertheless, the proportion of individuals with less than 5 ng of serum MBP per ml was significantly larger in the patient group (21%, P = 0.01) than in the control group (4%). Group II consisted of 73 pediatric and 56 adult patients with recurrent infections. Pediatric patients had significantly lower mean concentrations of serum MBP than their controls (P < 0.005), and there was no significant difference between the concentrations in sera of adult patients and adult controls (P < 0.4). Again, the proportion of individuals with less than 5 ng of serum MBP per ml was significantly larger in both pediatric (22%, P = 0.045) and adult (38%, P = 0.000016) patients than in their respective controls (4%). Our results demonstrate that, as in children, low concentrations of serum MBP can be associated with recurrent infections in adults.
低浓度的甘露糖结合蛋白（MBP；也称为甘露糖结合凝集素）与免疫缺陷儿童常见的调理素缺陷有关。我们比较了47名患有非人类免疫缺陷病毒相关反复感染的成年人（第一组）和50名健康成年对照组血清中MBP的浓度。患者组的平均血清MBP浓度与对照组相比无显著差异（P < 0.4）。然而，每毫升血清MBP低于5 ng的个体比例在患者组（21%，P = 0.01）中显著高于对照组（4%）。第二组由73名儿科和56名患有反复感染的成年患者组成。儿科患者的血清MBP平均浓度显著低于其对照组（P < 0.005），成年患者血清浓度与成年对照组之间无显著差异（P < 0.4）。同样，每毫升血清MBP低于5 ng的个体比例在儿科患者（22%，P = 0.045）和成年患者（38%，P = 0.000016）中均显著高于各自的对照组（4%）。我们的结果表明，与儿童一样，低浓度的血清MBP可能与成年人的反复感染有关。
