Micklefield G H
Medizinische Klinik, Ferdinand-Sauerbruch-Klinikum Wuppertal, Klinikum Wuppertal GmbH.
Z Arztl Fortbild Qualitatssich. 1998 Apr;92(3):195-8.
Gastroesophageal reflux may be responsible for atypical extra-esophageal symptoms, such as chest pain, dyspnea, chronic cough, or hoarseness. Prospective studies of gastroesophageal reflux have indicated reflux as the cause for chronic cough in 10 to 20% of patients. The precise mechanism by which reflux causes cough remains uncertain, although the possibility that the cough is caused by stimulation of the esophageal mucosa receptors rather than aspiration is suggestive from some studies. Prolonged esophageal pH monitoring affords an opportunity to document objective gastroesophageal reflux. Furthermore, pH monitoring gives the opportunity to correlate temporally acid reflux events with the onset of certain symptoms.
胃食管反流可能是导致非典型食管外症状的原因，如胸痛、呼吸困难、慢性咳嗽或声音嘶哑。对胃食管反流的前瞻性研究表明，在10%至20%的患者中，反流是慢性咳嗽的病因。尽管一些研究提示咳嗽可能是由食管黏膜感受器受刺激而非误吸引起，但反流导致咳嗽的确切机制仍不确定。长时间食管pH监测为记录客观的胃食管反流提供了机会。此外，pH监测还能将酸反流事件与某些症状的发作在时间上关联起来。
