三有机锡2-苯基-1,2,3-三唑-4-羧酸盐的合成、表征及生物活性
Synthesis, characterization and biological activity of triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates.
作者信息
Tian Laijin, Sun Yuxi, Li Huijun, Zheng Xiaoliang, Cheng Yuanzheng, Liu Xueli, Qian Bochu
机构信息
Department of Chemistry, Qufu Normal University, Qufu 273165, PR China.
出版信息
J Inorg Biochem. 2005 Aug;99(8):1646-52. doi: 10.1016/j.jinorgbio.2005.05.006.
The triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates, 2-PhC2N3CO2SnR3 (R=C6H5, 1; c-C6H11, 2; C6H5C(CH3)2CH2, 3), have been prepared and characterized by means of elemental analysis, IR and NMR (1H, 13C and 119Sn) spectroscopy. The crystal structures of 1 and 3 have been determined. Compound 1 is polymeric in nature with a trigonal bipyramidal configuration, and compound 3 shows a tetrahedral geometry. Bioassay results have shown that these compounds have good antibacterial and antitumor activity. The activity against three human tumor cell lines (HeLa, CoLo205 and MCF-7) decreased in the order 1>2>3.
已制备出三有机锡 2-苯基-1,2,3-三唑-4-羧酸盐，即 2-PhC₂N₃CO₂SnR₃（R = C₆H₅，1；c-C₆H₁₁，2；C₆H₅C(CH₃)₂CH₂，3），并通过元素分析、红外光谱和核磁共振（¹H、¹³C 和 ¹¹⁹Sn）光谱对其进行了表征。已测定出 1 和 3 的晶体结构。化合物 1 本质上是聚合物，具有三角双锥构型，化合物 3 呈现四面体几何形状。生物测定结果表明，这些化合物具有良好的抗菌和抗肿瘤活性。对三种人类肿瘤细胞系（HeLa、CoLo205 和 MCF-7）的活性顺序为 1>2>3。
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