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DAP genes: novel apoptotic genes isolated by a functional approach to gene cloning.

作者信息

Kimchi A

机构信息

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

出版信息

Biochim Biophys Acta. 1998 Apr 17;1377(2):F13-33. doi: 10.1016/s0304-419x(98)00002-x.

DOI:10.1016/s0304-419x(98)00002-x
PMID:9606974
Abstract
摘要

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DAP genes: novel apoptotic genes isolated by a functional approach to gene cloning.DAP基因：通过基因克隆功能方法分离出的新型凋亡基因。
Biochim Biophys Acta. 1998 Apr 17;1377(2):F13-33. doi: 10.1016/s0304-419x(98)00002-x.
2
Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions.死亡相关蛋白（DAPs）：从基因鉴定到其凋亡和肿瘤抑制功能分析
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DAP kinase and DAP-3: novel positive mediators of apoptosis.死亡相关蛋白激酶和死亡相关蛋白-3：凋亡的新型正向介质
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4
DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain.DAP激酶参与肿瘤坏死因子-α和Fas诱导的细胞凋亡，其功能需要死亡结构域。
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DAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer.死亡相关蛋白激酶：从功能基因克隆到其在细胞凋亡和癌症中作用的确立
Cell Death Differ. 2001 Jan;8(1):6-15. doi: 10.1038/sj.cdd.4400794.
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Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.鉴定一种新型丝氨酸/苏氨酸激酶和一种新型15-kD蛋白作为γ干扰素诱导细胞死亡的潜在介质。
Genes Dev. 1995 Jan 1;9(1):15-30. doi: 10.1101/gad.9.1.15.
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The death domain: a module shared by proteins with diverse cellular functions.
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DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells.死亡相关蛋白激酶（DAP激酶）活性对于C2-神经酰胺诱导的PC12细胞凋亡至关重要。
Eur J Biochem. 2002 Jan;269(1):139-47. doi: 10.1046/j.0014-2956.2002.00029.x.
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A functional genetic screen identifies regions at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity.一项功能基因筛选确定了死亡相关蛋白激酶的C末端尾部和死亡结构域中对其促凋亡活性至关重要的区域。
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The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases.DAP激酶蛋白家族：一组新型钙调节促死亡激酶的研究
Biochim Biophys Acta. 2002 Nov 4;1600(1-2):45-50. doi: 10.1016/s1570-9639(02)00443-0.

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钙调神经磷酸酶同源蛋白：一个多功能的钙离子结合蛋白家族。
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Identification of a structural motif in the tumor-suppressive protein GRIM-19 required for its antitumor activity.鉴定抑瘤蛋白 GRIM-19 中其抗肿瘤活性所必需的结构基序。
Am J Pathol. 2010 Aug;177(2):896-907. doi: 10.2353/ajpath.2010.091280. Epub 2010 Jul 1.
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The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.细胞死亡调节因子GRIM-19是信号转导和转录激活因子3的抑制剂。
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9342-7. doi: 10.1073/pnas.1633516100. Epub 2003 Jul 16.
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Novel retroviral vectors to facilitate expression screens in mammalian cells.用于促进哺乳动物细胞表达筛选的新型逆转录病毒载体。
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Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.死亡相关蛋白激酶相关蛋白1，一种参与细胞凋亡的新型丝氨酸/苏氨酸激酶。
Mol Cell Biol. 2000 Feb;20(3):1044-54. doi: 10.1128/MCB.20.3.1044-1054.2000.
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A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation.一种新型的DAP5蛋白由于半胱天冬酶切割和内部核糖体进入位点介导的翻译而在凋亡细胞中积累。
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