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关于诊断试验信息含量的思考(作者译)

[Considerations on the information content of diagnostic tests (author's transl)].

作者信息

Borkenstein J, Goebel R

出版信息

Wien Klin Wochenschr. 1976 Jul 16;88(14):460-3.

PMID:960705
Abstract

The value of a diagnostic test lies in its ability to support the doctor's efforts to detect a certain disease. The aim is to achieve the highest possible probability that the disease is correctly diagnosed by means of the test. Doctors are not always aware of the extent to which a test can contribute to the final diagnosis. This contribution, the information content of the test, can be calculated by various algebraic manipulations. An example (carcinoembryonic antigen) is given, which demonstrates the significance of certain terms such as true and false positive results or likelihood and, moreover, the application of Baye's theorem.

摘要

诊断测试的价值在于其支持医生检测某种疾病的能力。目的是通过该测试实现疾病被正确诊断的可能性最大化。医生并不总是清楚一项测试对最终诊断的贡献程度。这种贡献,即测试的信息含量,可以通过各种代数运算来计算。给出了一个例子(癌胚抗原),它展示了诸如真阳性和假阳性结果或似然性等特定术语的重要性,此外还展示了贝叶斯定理的应用。

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