Braissant O, Wahli W
Institut de Biologie Animale, Université de Lausanne, Switzerland.
Endocrinology. 1998 Jun;139(6):2748-54. doi: 10.1210/endo.139.6.6049.
The expression patterns of the three different peroxisome proliferator-activated receptor (PPAR) isotypes have been determined during rat embryonic development by in situ hybridization. The expression of PPARalpha starts late in development, with increasing levels in organs such as liver, kidney, intestine, and pancreas, in which it will also be present later in adulthood to regulate its specific target genes. PPARalpha is also transiently expressed in the embryonic epidermis and central nervous system. PPARgamma presents a very restricted pattern of expression, being strongly expressed in brown adipose tissue, in which differentiation it has been shown to participate. Like PPARalpha, it is also expressed transiently in the central nervous system. Interestingly, PPARalpha, -beta and -gamma are coexpressed at high levels in brown adipose tissue. Finally, the high and ubiquitous expression of PPARbeta suggests some fundamental role(s) that this receptor might play throughout development.
通过原位杂交技术，已确定了三种不同的过氧化物酶体增殖物激活受体（PPAR）亚型在大鼠胚胎发育过程中的表达模式。PPARα在发育后期开始表达，在肝脏、肾脏、肠道和胰腺等器官中的表达水平逐渐升高，在成年期这些器官中它也会存在以调节其特定的靶基因。PPARα在胚胎表皮和中枢神经系统中也有短暂表达。PPARγ呈现出非常局限的表达模式，在棕色脂肪组织中强烈表达，已证明它参与该组织的分化。与PPARα一样，它在中枢神经系统中也有短暂表达。有趣的是，PPARα、-β和-γ在棕色脂肪组织中高水平共表达。最后，PPARβ的高表达且广泛存在表明该受体在整个发育过程中可能发挥一些基本作用。
