Fryauff D J, Cryz S J, Widjaja H, Mouzin E, Church L W, Sutamihardja M A, Richards A L, Subianto B, Hoffman S L
US Naval Medical Research Unit No. 2, Jakarta, Indonesia.
J Infect Dis. 1998 Jun;177(6):1762-5. doi: 10.1086/517441.
Immune suppression resulting from prolonged chemoprophylaxis and potential drug-vaccine interaction were investigated within the context of a randomized placebo-controlled trial that compared daily primaquine or weekly chloroquine administration for malaria prevention. After 11 months of prophylaxis, adult male subjects received a tetanus-diphtheria (Td) vaccination. Prophylaxis continued 4 weeks longer. Anti-tetanus and anti-diphtheria antibody levels were measured by ELISA at baseline and at 1, 3, 7, and 14 months after Td vaccination. All groups were comparable at baseline. Immunization triggered significant increases in anti-tetanus and anti-diphtheria IgG levels over each group's pre-Td baseline levels and those of an unvaccinated control group. Geometric mean anti-tetanus titers (GMTs) in the primaquine group were significantly higher than those of the placebo group at 1, 3, and 14 months. Anti-tetanus GMTs in placebo and chloroquine groups declined over 14 months to levels comparable to those of unvaccinated controls, but levels in the primaquine group remained significantly higher than in controls.
在一项随机安慰剂对照试验的背景下，研究了长期化学预防导致的免疫抑制以及潜在的药物 - 疫苗相互作用。该试验比较了每日服用伯氨喹或每周服用氯喹预防疟疾的效果。在预防11个月后，成年男性受试者接受了破伤风 - 白喉（Td）疫苗接种。预防措施又持续了4周。通过酶联免疫吸附测定法（ELISA）在基线以及Td疫苗接种后的1、3、7和14个月测量抗破伤风和抗白喉抗体水平。所有组在基线时具有可比性。免疫接种使每组接种Td前的基线水平以及未接种疫苗的对照组的抗破伤风和抗白喉IgG水平显著升高。在1、3和14个月时，伯氨喹组的几何平均抗破伤风滴度（GMTs）显著高于安慰剂组。安慰剂组和氯喹组的抗破伤风GMTs在14个月内下降至与未接种疫苗的对照组相当的水平，但伯氨喹组的水平仍显著高于对照组。
