Wykrzykowska J J, Rosenzweig M, Veazey R S, Simon M A, Halvorsen K, Desrosiers R C, Johnson R P, Lackner A A
New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA.
J Exp Med. 1998 Jun 1;187(11):1767-78. doi: 10.1084/jem.187.11.1767.
The thymus plays a critical role in the maturation and production of T lymphocytes and is a target of infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7-14 d after infection, followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4(+) T cell counts.
胸腺在T淋巴细胞的成熟和产生过程中发挥着关键作用，并且是人类免疫缺陷病毒（HIV）及相关的猴免疫缺陷病毒（SIV）的感染靶标。利用艾滋病的SIV/猕猴模型，我们研究了SIV对胸腺的早期影响。我们发现，SIV感染胸腺后，在感染后7 - 14天导致细胞凋亡增加，到第21天胸腺细胞祖细胞耗竭。到第50天胸腺细胞祖细胞出现显著反弹，并伴有胸腺中细胞增殖水平增加。我们的结果表明，在SIV感染过程的很早阶段，远在外周CD4(+) T细胞计数显著下降之前，胸腺祖细胞活性就有显著增加。
Zotero 插件
