Daniluk J, Kandefer-Szerszeń M
Katedra i Klinika Gastroenterologii Akademii Medycznej, Lublinie.
Postepy Hig Med Dosw. 1998;52(1):49-65.
Chronic alcoholism is a disease, which is known to affect individual's resistance to infections. Alcohol has a variety of short- and long-term effects on cell mediated and humoral immune response. Alcohol also affects the production, site of action and metabolism of cytokines, which are regulatory peptides of the immune and inflammatory response of lymphocytes, monocytes/macrophages and a variety of other cell types. In this review, current knowledge regarding the effect of alcohol on the immune system and the release and action of cytokines in humans and in animal models, in vivo and in vitro, is presenting. Furthermore, the role of cytokines in development of alcoholic liver disease is also discussed.
慢性酒精中毒是一种已知会影响个体抗感染能力的疾病。酒精对细胞介导的免疫反应和体液免疫反应有多种短期和长期影响。酒精还会影响细胞因子的产生、作用部位和代谢，细胞因子是淋巴细胞、单核细胞/巨噬细胞以及多种其他细胞类型免疫和炎症反应的调节肽。在这篇综述中，介绍了目前关于酒精对人类和动物模型体内外免疫系统以及细胞因子释放和作用影响的知识。此外，还讨论了细胞因子在酒精性肝病发展中的作用。
