Trzepacz P T, Mulsant B H, Dew M A, Pasternak R, Sweet R A, Zubenko G S
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA.
J Neuropsychiatry Clin Neurosci. 1998 Spring;10(2):199-204. doi: 10.1176/jnp.10.2.199.
The authors studied 61 geropsychiatric patients with delirium from a cohort of 843 consecutive admissions to a geriatric clinical research unit. A central study goal was to assess how the presence of dementia affected the presentation of delirium. Eighteen delirious (D) and 43 delirious-demented (D-D) patients were compared on the Delirium Rating Scale (DRS), Mini-Mental State Examination (MMSE), Brief Psychiatric Rating Scale (BPRS), and EEG. D-D patients had lower MMSE scores, but no differences were found in total DRS or BPRS scores or in EEG grade. DRS items were similar in the two groups except that D-D had more cognitive impairment than D. An exploratory principal components analysis of DRS items identified two core factors. The authors conclude that the presentation of delirium in the setting of concurrent dementia is very similar to delirium without dementia, with subtle differences probably attributable to dementia.
作者对老年临床研究单元连续收治的843例患者中的61例患有谵妄的老年精神科患者进行了研究。一项核心研究目标是评估痴呆症的存在如何影响谵妄的表现。对18例谵妄（D）患者和43例谵妄-痴呆（D-D）患者进行了谵妄评定量表（DRS）、简易精神状态检查表（MMSE）、简明精神病评定量表（BPRS）和脑电图（EEG）方面的比较。D-D患者的MMSE评分较低，但在DRS或BPRS总分或EEG分级方面未发现差异。两组的DRS项目相似，只是D-D患者的认知障碍比D组更多。对DRS项目进行的探索性主成分分析确定了两个核心因素。作者得出结论，并发痴呆症情况下的谵妄表现与无痴呆症的谵妄非常相似，细微差异可能归因于痴呆症。
