Goshorn R K
Department of Internal Medicine, Indiana University Hospital, Indianapolis, USA.
Semin Neurol. 1998;18(2):237-42. doi: 10.1055/s-2008-1040876.
Syndromes characterized by persistent fatigue, musculoskeletal pain, sleep disturbance, and subjective cognitive impairment have been common problems in clinical practice for decades. The chronic fatigue syndrome case definition was created to standardize the patient population in research studies and to foster a systematic and comprehensive approach to the attempt to define the etiology and pathophysiology of these syndromes. The pathogenesis of chronic fatigue syndrome remains unknown, though it does appear to be associated with subtle neuroendocrine and immunologic abnormalities. Treatment of chronic fatigue syndrome is empirical. Significant palliation is often possible, though treatment success requires skillful practice of the art of medicine.
以持续疲劳、肌肉骨骼疼痛、睡眠障碍和主观认知损害为特征的综合征在临床实践中已存在数十年，一直是常见问题。慢性疲劳综合征病例定义的制定是为了在研究中规范患者群体，并促进采用系统全面的方法来试图明确这些综合征的病因和病理生理学。尽管慢性疲劳综合征的发病机制似乎与细微的神经内分泌和免疫异常有关，但其仍不明。慢性疲劳综合征的治疗是经验性的。虽然治疗成功需要精湛的医术，但显著缓解症状通常是可能的。
