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[哮喘患者与健康受试者外周血及鼻黏液中的嗜酸性粒细胞]

[Eosinophils in peripheral blood and nasal mucus, in asthmatic and healthy subjects].

作者信息

Vázquez Nava F, Salvador Casados Robledo J, Salazar Herrera F

机构信息

Departamento de alergia e inmunología clínica, Hospital General Regional núm. 6, IMSS, Ciudad Madero, Tamaulipas.

出版信息

Rev Alerg Mex. 1998 Jan-Feb;45(1):4-8.

PMID:9608778
Abstract

MATERIAL AND METHODS

600 subjects were studied, chosen at random, between 1 and 55 years old, 300 asthmatic and the rest apparently healthy.

RESULTS

Of 300 asthmatic patients, the average concentration of eosinophils in peripheral blood was of 615.93/mm3 (p = 0.000004, R = 2.13), the asthmatic patients with levels of eosinophils over a 400/mm3 presented: more severe asthma per month and made use of hospital services more often, (p = 0.00001, R = 3.56). In 195 patients were detected eosinophils in nasal mucus with an average concentration of 10.54% (p = 0.04, R = 0.70).

CONCLUSIONS

The incidence and prevalence of asthma seem favored by the lact of predictive sensors. In the study, the blood and nasal eosinophils, in high levels were identified in subjects at high risk, consequently its use is proposed to diagnose and follow up, with the goal of applying measures in the balanced phase of the health-illness chain.

摘要

材料与方法

对600名年龄在1至55岁之间的受试者进行了随机研究,其中300名为哮喘患者,其余为明显健康者。

结果

在300名哮喘患者中,外周血嗜酸性粒细胞的平均浓度为615.93/mm³(p = 0.000004,R = 2.13),嗜酸性粒细胞水平超过400/mm³的哮喘患者表现为:每月哮喘更严重且更频繁地使用医院服务,(p = 0.00001,R = 3.56)。在195名患者的鼻黏液中检测到嗜酸性粒细胞,平均浓度为10.54%(p = 0.04,R = 0.70)。

结论

哮喘的发病率和患病率似乎受到预测传感器缺失的影响。在该研究中,在高危受试者中发现血液和鼻嗜酸性粒细胞水平较高,因此建议将其用于诊断和随访,目的是在健康 - 疾病链的平衡阶段采取措施。

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Rev Alerg Mex. 1998 Jan-Feb;45(1):4-8.
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