Szyguła J, Puzio B, Poloński L
II Katedry i Kliniki Kardiologii Slaskiej Akademii Medycznej w Katowicach.
Wiad Lek. 1998;51(1-2):76-81.
PTCA is a new method of invasive cardiology. Restenosis is an important limitation of efficacy of this method. It occurs in 20-45% of patients. Pathomechanism of the restenosis is not clear. It is assumed, that restenosis is an answer of the endothelium to the procedure. This response consists of the inflammation, platelet primary adhesion and aggregation, proliferation of smooth muscle cells and intercellular matrix production. These changes together with old atheroma and thrombus create a new stenosis. There were many attempts to prevent restenosis based on the pathophysiology, but so far no successful method has been found.
经皮冠状动脉腔内血管成形术（PTCA）是侵入性心脏病学的一种新方法。再狭窄是该方法疗效的一个重要限制因素。它发生在20%至45%的患者中。再狭窄的发病机制尚不清楚。据推测，再狭窄是内皮对该手术的一种反应。这种反应包括炎症、血小板的初始黏附和聚集、平滑肌细胞增殖以及细胞间基质产生。这些变化与陈旧性动脉粥样硬化和血栓一起形成新的狭窄。基于病理生理学有许多预防再狭窄的尝试，但迄今为止尚未找到成功的方法。
