Jobe A H, Wada N, Berry L M, Ikegami M, Ervin M G
Department of Pediatrics, Harbor-University of California, Torrance, USA.
Am J Obstet Gynecol. 1998 May;178(5):880-5. doi: 10.1016/s0002-9378(98)70518-6.
We evaluated the effects of single or three repeated doses of maternal betamethasone on fetal growth at preterm and term delivery in sheep.
Pregnant ewes were randomly assigned to receive one dose of 0.5 mg/kg betamethasone at 104 days' gestational age; three doses of betamethasone at 104, 111, and 118 days' gestational age; or saline for controls. Lambs were delivered at 125 days' (preterm) or at 145 days' (term) gestational age for assessments of fetal growth.
The single betamethasone exposure at 104 days' gestational age caused symmetric growth retardation of 11% at 125 days' gestational age and 14% at term. The three-dose exposures decreased body weights by 25% in preterm lambs and by 19% at term. Organ protein and deoxyribonucleic acid per kilogram of body weight were selectively decreased in preterm lambs. At term the decreases in organ weight, protein, and deoxyribonucleic acid were proportionate to the decreased birth weight.
One or three doses of maternal glucocorticoids begun at an early gestational age caused symmetric growth retardation in lambs delivered prematurely, and the decreased fetal size persisted to term.
我们评估了单次或三次重复剂量的母体倍他米松对绵羊早产和足月分娩时胎儿生长的影响。
将怀孕母羊随机分为三组，分别在妊娠104天时接受一剂0.5mg/kg倍他米松；在妊娠104天、111天和118天时接受三剂倍他米松；或注射生理盐水作为对照。在妊娠125天（早产）或145天（足月）时分娩羔羊，以评估胎儿生长情况。
在妊娠104天时单次暴露于倍他米松会导致妊娠125天时胎儿对称生长迟缓11%，足月时为14%。三次剂量暴露使早产羔羊体重下降25%，足月时下降19%。早产羔羊每千克体重的器官蛋白和脱氧核糖核酸选择性降低。足月时，器官重量、蛋白和脱氧核糖核酸的降低与出生体重的降低成比例。
在妊娠早期开始使用一剂或三剂母体糖皮质激素会导致早产羔羊出现对称生长迟缓，且胎儿体型减小的情况会持续至足月。
