Nuhoğlu Y, Dai A, Barlan I B, Başaran M M
Marmara University Hospital, Department of Pediatrics, Istanbul, Turkey.
Ann Allergy Asthma Immunol. 1998 May;80(5):395-8. doi: 10.1016/S1081-1206(10)62990-0.
The role of aminophylline (ethylene diamine salt of theophylline) in the treatment of acute exacerbation of asthma has not been well established in children.
The aim of the study was to determine the additional therapeutic benefit of intravenous aminophylline in the treatment of children hospitalized for acute asthmatic exacerbation and treated with inhaled bronchodilators and glucocorticoid therapy.
Thirty-eight children aged from 2 to 16 years (mean age 5.64 +/- 3.31), admitted for acute exacerbation of asthma, participated in a prospective, randomized, double-blind, placebo-controlled study. All the subjects received methylprednisolone, administered intravenously, and nebulized salbutamol. The treatment group received intravenous aminophylline therapy and the placebo group received 0.9% saline solution for 24 hours.
The number of salbutamol nebulizations needed and the clinical asthma scoring were recorded both at onset and at the end of 24 hours. There was no significant difference in either the mean number of nebulizations or the clinical asthma scores between the two groups (P = .7843, P = .8452).
Intravenous aminophylline (ethylene diamine salt of theophylline) demonstrated no additional beneficial effect to the combination of beta adrenergic agonists and glucocorticoid treatment in acute asthma attack in children.
氨茶碱（茶碱乙二胺盐）在儿童哮喘急性加重期治疗中的作用尚未明确。
本研究旨在确定静脉注射氨茶碱对因哮喘急性加重住院且接受吸入性支气管扩张剂和糖皮质激素治疗的儿童的额外治疗益处。
38名年龄在2至16岁（平均年龄5.64±3.31岁）的因哮喘急性加重入院的儿童参与了一项前瞻性、随机、双盲、安慰剂对照研究。所有受试者均接受静脉注射甲泼尼龙和雾化沙丁胺醇治疗。治疗组接受静脉注射氨茶碱治疗，安慰剂组接受0.9%生理盐水治疗，持续24小时。
记录了治疗开始时和24小时结束时所需的沙丁胺醇雾化次数以及临床哮喘评分。两组之间的雾化平均次数或临床哮喘评分均无显著差异（P = 0.7843，P = 0.8452）。
在儿童急性哮喘发作中，静脉注射氨茶碱（茶碱乙二胺盐）对β肾上腺素能激动剂和糖皮质激素联合治疗未显示出额外的有益效果。
