Yasuda S, Shohtsu A, Ide M, Takagi S, Takahashi W, Suzuki Y, Horiuchi M
HIMEDIC Imaging Center at Lake Yamanaka, Yamanashi, Japan.
Radiology. 1998 Jun;207(3):775-8. doi: 10.1148/radiology.207.3.9609903.
To determine the frequency and clinical importance of diffuse 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) uptake in the thyroid gland.
A total of 1,102 healthy subjects underwent whole-body positron emission tomography (PET). PET images were evaluated for increased diffuse FDG uptake in the thyroid gland. Serum free thyroxine and thyrotropin levels were measured in 36 subjects with increased uptake and in 36 matched control subjects without uptake. Antithyroid antibodies were also measured. Morphologic abnormalities were examined by using ultrasonography (US).
Diffuse FDG uptake was found in three men and 33 women; the prevalence was significantly higher in women (P < .01). Thirty-five subjects were euthyroid; one had hypothyroidism. Antithyroid antibodies were positive in 27 subjects. In most subjects, US findings facilitated the diagnosis of chronic thyroiditis. In control subjects, the positive rates for antithyroid antibodies and US abnormalities were significantly lower than those of the study group (P < .01).
Diffuse thyroidal FDG uptake may be an indicator of chronic thyroiditis. The actual prevalence of the disorder was not low in this series, and such lesions may be found incidentally at FDG PET.
确定甲状腺弥漫性摄取2-[氟-18]氟-2-脱氧-D-葡萄糖（FDG）的频率及其临床意义。
共有1102名健康受试者接受了全身正电子发射断层扫描（PET）。对PET图像进行评估，以确定甲状腺是否存在弥漫性FDG摄取增加。对36名摄取增加的受试者和36名匹配的无摄取的对照受试者测量血清游离甲状腺素和促甲状腺激素水平。还检测了抗甲状腺抗体。通过超声检查（US）检查形态学异常。
在3名男性和33名女性中发现了弥漫性FDG摄取；女性患病率显著更高（P <.01）。35名受试者甲状腺功能正常；1名患有甲状腺功能减退。27名受试者抗甲状腺抗体呈阳性。在大多数受试者中，超声检查结果有助于诊断慢性甲状腺炎。在对照受试者中，抗甲状腺抗体阳性率和超声异常率显著低于研究组（P <.01）。
甲状腺弥漫性FDG摄取可能是慢性甲状腺炎的一个指标。在本系列中，该疾病的实际患病率并不低，并且此类病变可能在FDG PET检查时偶然发现。
