Chen X, Schwarz K Q, Phillips D, Steinmetz S D, Schlief R
Department of Medicine, University of Rochester, NY 14642, USA.
IEEE Trans Biomed Eng. 1998 Jun;45(6):754-65. doi: 10.1109/10.678610.
A mathematical model for the assessment of hemodynamic parameters using quantitative echocardiography is presented. The method involves the intravenous injection of an ultrasonic echo contrast agent. The relative enhancement of the backscattered ultrasound intensity is measured as a function of time (the time-intensity curve). From this measurement, the volume flow rate (cardiac output) and the mixing volume are calculated. Relevant acoustic properties of the ultrasound contrast agent are discussed. An in vitro experiment is performed to corroborate the theory presented.
本文提出了一种使用定量超声心动图评估血流动力学参数的数学模型。该方法包括静脉注射超声回声造影剂。测量反向散射超声强度随时间的相对增强情况（时间-强度曲线）。根据该测量结果计算体积流量（心输出量）和混合体积。讨论了超声造影剂的相关声学特性。进行了一项体外实验以证实所提出的理论。
