Davie J R
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Curr Opin Genet Dev. 1998 Apr;8(2):173-8. doi: 10.1016/s0959-437x(98)80138-x.
Recent advances highlight the involvement of histone acetyltransferases in transcriptional activation and histone deacetylases in transcriptional repression. Transcription factors loaded onto regulatory DNA elements may recruit either coactivators with histone acetyltransferase activity or corepressors associated with histone deacetylases. The recruited enzymes may either acetylate or deacetylate proximal nucleosomal histones or nonhistone chromosomal proteins.
最近的进展突出了组蛋白乙酰转移酶在转录激活中的作用以及组蛋白去乙酰化酶在转录抑制中的作用。结合到调控DNA元件上的转录因子可能募集具有组蛋白乙酰转移酶活性的共激活因子或与组蛋白去乙酰化酶相关的共抑制因子。募集到的酶可能使近端核小体组蛋白或非组蛋白染色体蛋白发生乙酰化或去乙酰化。
